Enzyme responsive luminescent ruthenium(II) cephalosporin probe for intracellular imaging and photoinactivation of antibiotics resistant bacteria.
نویسندگان
چکیده
The Főrster resonance energy transfer (FRET) based luminescent ruthenium(II) cephalosporin probe has been designed and synthesized, which can be selectively activated by endogenous β-lactamases and thus provided a localized and specific intracellular luminescence imaging and photoinactivation of drug resistant bacterial pathogens.
منابع مشابه
Enzyme responsive luminescent ruthenium(II) cephalosporin probe for intracellular imaging and photoinactivation of antibiotics resistant bacteriaw
Since the last century, b-lactam antibiotics such as penicillins and cephalosporins have been well developed as a major class of antimicrobial agents to treat bacterial infections in clinics. However, the prevalence of b-lactam antibiotic resistant bacterial strains, especially for those of methicillin-resistant Staphylococcus aureus (MRSA), has emerged as a public health crisis. One most remar...
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عنوان ژورنال:
- Chemical communications
دوره 48 12 شماره
صفحات -
تاریخ انتشار 2012